This is entirely possible. Assuming you are running Google Analytics Version 5 (the new interface):

    1. Go to "Custom Reports" (top navigation)
    2. Click on "+New Custom Report"
    3. And set the following:
     a. +add metric: Entrances, Bounces, Unique Visitors, Pageviews, Avg. Time on Page, Avg. Time on Site
     b. +add dimension: Day of Week, Page Title, Visitor Type, City, and whatever you like
    4. Enter filters:
     a. Exclude "Day of Week" Exact 0 (that's Sunday)
     b. Exclude "Day of Week" Exact 6 (that's Saturday)

Or for easy reference I have already set it up and shared:
[Performance Weekdays: Click me][1]


  [1]: https://www.google.com/analytics/web/crPermalink?data=AH4sIAAAAAAAAAHWPwUrDQBCGs1FEFpEYFdfFQ9ibPUhEUfDkQfAkFhra8xqnZTDNht1JJI_ga7QP4Cua6GGrmOv3_TPzT2x4EAt-NAY7N3apyxySGcDbq25dFKhDXeqiJczdBZRke-1GZ3wDd8HneT8Rs1SwhA3am96mTH6GfPsyvbrttg_eXe18hHzN-uB1KiO-9wRkMU8eramrgVrqwMMXU3-jE4_IkC6m6JCMdZsLKr2ABuHdqVMPdbMYd_yhtprQlEr8UhNwrqMZLmE0k_-9q-7lnxMZUgHqXB573Py0ydoKVCT3vciR2rtdEQgmQrH1BYtDXY2jAQAA