For the iPhone in particular you should consider configuring the viewport, which controlsthe scale at which your page will get rendered. This is especially useful if your site is significantly narrower than the default viewport width of 980px. You can do this with a meta tag:
<meta name = "viewport" content = "width = 590">
You can also set the scale, and a bunch of other things. You can read all the details on Apple's site: http://developer.apple.com/safari/library/documentation/appleapplications/reference/safariwebcontent/usingtheviewport/usingtheviewport.html