The intelligence of the blocker is down to whatever extension or software the user is using. Some will simply block adsense, while others may be configured to read a white list, or black list configuration.
Typically a site with its own ad-network shouldn't be a problem unless the site is used by hundreds of thousands of people, then you may have people submitting your site to the blacklist if the users are finding your site annoying, advert excessive or slow.
There are however more intelligent ad blockers that look for a range of things such as:
- Adobe Flash Prevention
- ActiveX Prevention
- Cookie Tracking Prevention
- HTML Video Prevention
- Domain/URL Blocking
- Popup Prevention
- New Tab Prevention
As far as I know there's no super smart adblocker with a clever algorithm to detect ads that are not within their database, they are mostly community driven databases. Generally Flash based adverts tend to be blocked the most because like myself and millions of others hate flash, it regularly locks up the browser window, so people use click to consent type blocks, this is also expanding to HTML 5 video since adversities have started to auto play HTML5 videos if flash is blocked.
Most sites don't get submitted to these databases and most blockers will only accept sites that are reported by X amount of users and serve a lot of ads.
If you want to avoid being put on the naughty lists then don't serve too many ads, generally sites with only 1 ad don't get added. If your have many ads on the pages then you should expect users to submit this data. Ensure your ads are fast and video ads don't auto execute as that's number 1 way of getting on the list.
End of the day, most adblockers authors want sites to be supported, so if your site is:
- Good quality
- Not excessive in how many ads you use
- Relevant adverts
Then you should be ok.... however, a lot of adnetworks monitor cookies, this is also another reason why people block, they want their privacy respected. Not matter how good your site is you will get people block... and there is no 100% solution around this, if there was and I knew what it was then I'd be a billionaire sipping cocktails on my Island called Isle of Simon!