I have a fairly large newsletter that goes out daily. I setup the newsletter originally to send from firstname.lastname@example.org (an inbox I actively use); it has been sending from that email for almost two years and when I setup it up originally, I did not realize the amount of auto responders I'd get clogging up my inbox.
Recently, I modified my newsletter to send from email@example.com but reply-to firstname.lastname@example.org, an inbox that sends out canned responses. This cut down on the majority of auto responders but some are still getting through. As such, I'm thinking of setting both send and reply-to addresses to email@example.com. However, I'm afraid I may kill deliverability if I do this. Any thoughts? If the two emails are on the same domain, will it affect deliverability? If it will, are there any other options that I could employ?