My first thought when reading the question was that this is going to be a case for the web-spam team. Please don't create tons of sites that are essentially doorway pages. Also, using wildcard subdomains (assuming the idea is to map them to cities after DNS resolution) make it extremely hard to determine how those URLs should be crawled.
Additionally, I think it's important to mention that a site using this kind of URL structure won't see any unnatural advantage in search. Search engines are just as good at handling URL parameters, there's no need to make it look like a website focused on [cityname],[countryname] when it's essentially just a part of the same website. Unless you have very good reasons to do this outside of web-search, I would recommend simplifying things significantly.
For geotargeting, using a ccTLD is a good way to let users & search engines know about your target audience. For Google, you can also use a gTLD (even the same one for all your sites) and work with subdirectories or subdomains to apply geotargeting there too. That saves you from having to get & maintain all those ccTLDs.
For multilingual content, at least from Google's point of view, the URL is irrelevant as long as it's unique. Use whatever URL structure works for you (and look into using hreflang where it makes sense).
.de
site is specifically targeting users in Germany? It's not simply that the site has German content, but could be of interest to those outside Germany?