I still remember one of my high school teachers lecturing us about the "web safe colors". A set of 216-256 colors that you should confine your designs to use, and nothing else besides them. Last I knew, Photoshop still has the "web safe" yield icon1 on it's color picker.
Are web safe colors still a concern? Outside of the obvious application (accessibility, legacy software versions, etc.), how much consideration should I give to limiting my color choice for my general audience?
1Or was it the cube? I never remember.