I'm planning to use Amazon S3 with Cloudfront as CDN network.
But I'm guessing that changing the url from
sub.domain.com will slow the process of download
Is this correct?
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It will make no difference. Clients have to make a DNS lookup to convert the name to an IP address; using a CNAME might make that slightly slower, but by tens of milliseconds. The download itself uses the IP address, and will be entirely unaltered.